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KMID : 0032220090210010060
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Annals of Dermatology
2009 Volume.21 No. 1 p.60 ~ p.62
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Repeated Paradoxical Aggravation of Preexisting Psoriasis during Infliximab Treatment for Crohn’s Disease.
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Park Byung-Cheol
Lee Weon-Ju
Lee Seok-Jong
Kim Do-Won
Lim Hyun-Jung
Kim Byung-Soo
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Abstract
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As more rheumatologists and dermatologists have begun to use biological agents such as TNF-alpha blocker, they have confronted an unexpected complication: psoriasis was paradoxically aggravated or induced by the TNF-alpha blocker. Although it is not a common complication of TNF-alpha blocker, this aggravation may be more common than previously thought. To our knowledge, most reports about TNF-alpha blocker-induced psoriasis have been limited to western countries while only a few cases have been reported in Korea and Japan. In addition, new onset of pustular psoriasis by TNF-alpha blocker has been reported more commonly than worsening of preexisting psoriasis. Now we report a patient whose preexisting psoriasis vulgaris was aggravated repeatedly after using the TNF-alpha blocker, infliximab, to control Crohn’s disease, which is a rare rheumatologic disease in Korea.
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KEYWORD
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Aggravation, Crohn’s disease, Psoriasis, TNF-α blocker
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